Green-Lipped Mussel

26 mins read

Green-lipped mussel is a dietary supplement drawn from a type of mussel native to New Zealand. We do not actually comprehend how it works, but it includes omega-3 fats, which have anti-inflammatory and joint-protecting residential or commercial properties. Proof recommends that it might be of some usage to people with osteoarthritis when taken along with paracetamol or non-steroidal anti-inflammatory drugs (nsaids). It’s ineffective in treating rheumatoid arthritis.

Household: Nutritional supplement

Scientific name: Perna canaliculus

Other names: New Zealand mussel, greenshell mussel, Seaton ®, GLM, Lyprinol
®. Green-lipped mussel is a dietary supplement taken from perna canaliculus, a bivalve mollusc (mussel) native to New Zealand. You can buy it from high-street retailers. (1 ).

Green-lipped mussels are loaded with nutrients

The green-lipped mussel is a staple food of the native Māori people of New Zealand’s coasts.

Interest in the mussel’s possible health advantages began in the early 1970s and came from the observation that Māori individuals had a lower incidence of arthritis than people who lived inland.

It was later determined that the mussels were a rich source of anti-inflammatory omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Additionally, researchers have actually recognized other kinds of fats from the mussels. They may also possess anti-inflammatory impacts by hindering enzymes and proteins that produce swelling and pain.

Similarly, green lipped-mussels consist of chondroitin sulfate, a component of connective tissues like joints and bones that may decrease swelling in the same way.

In addition to these anti-inflammatory nutrients, the mussels are a great source of zinc and an exceptional source of iron, selenium, and several B-vitamins. (2 ).

Mechanism of Action

An active ingredient in GLM is furan fats (F-acids). These are natural– however unusual and really potent– anti-oxidants. F-acids are fats frequently discovered in algae may discuss their anti-inflammatory homes and be among the main reason GLM is beneficial. (Another of GLM’s active ingredients lyprinol, a lipid extract, has properties comparable to other omega-3 polyunsaturated fatty acids, which may assist, too.).

Furan fatty acids are omega-3 fats, like those in fish oil, which inhibit 5′- lipoxygenase and cyclo-oxygenase paths, similar to anti-inflammatory medications, however without the side effects. The biochemical pathways blocked are responsible for the production of leukotrienes and prostaglandins, both chemicals which trigger swelling.

For those scientifically likely, this describes why GLM may be a helpful tool for asthma, osteoarthritis, and other inflammatory conditions such as rheumatoid arthritis. GLM also has a helpful impact on the gut microbiome.

Green Lipped Mussel is a Prebiotic

There are many health benefits to prebiotics. A practical food or supplement taken in by beneficial gut germs, probiotics assist enhance the gut microbiome. According to research studies, GLM acts as a nutrient for beneficial gut bacteria, which when taken in, encourages these healthy germs to produce short-chain fats (scfas), substances which apply many beneficial impacts throughout the body. This better state assists the body achieve balance, or homeostasis, allowing the body to operate at optimal levels and decrease systemic inflammation.


Asthma is a reversible inflammatory lung disease that occurs when the muscles surrounding the lung tissues constrict. During an asthma attack, it is difficult to breathe.

Worldwide, 300 million individuals are impacted with asthma while practically 250,000 people die from the condition each year. Throughout an asthma attack, an individual may experience signs like wheezing, coughing, and shortness of breath. Certain triggers, along with respiratory infections or, often, allergies to pollen or family pet dander, can bring on an attack. Obesity, specified in those with a body mass index of 30 or more, doubles a person’s danger for establishing asthma.

There is likewise a kind of asthma referred to as exercise-induced asthma (EIA), which happens during physical activity. Those who have this form of asthma regularly require to utilize their medications prior to or during workout in order to breathe easily. There are natural methods to asthma one can take, and GLM is one that some find useful.

GLM can be handy in decreasing asthma symptoms, according to a 2002 study. Even more, according to a 2013 research study, GLM could be useful in decreasing wheezing and shortness of breath, allowing those affected a minimized requirement for their rescue inhalers. If you are on medications, speak with your doctor prior to stopping any medications.


Osteoarthritis normally arises from basic “wear and tear” of the joints. It takes place due to the destruction of cartilage, which functions as a cushion that covers the bone. Early indications of osteoarthritis might start when a person is around 40 years old and can advance as one ages. The joints can be tender but are hardly ever inflamed.

Joint trauma, at any age, can likewise lead to osteoarthritis in the impacted joint. When my son Joshua remained in the 6th grade, he broke his elbow playing basketball. He went through surgical treatment to have actually a pin placed, so the bone could be returned in place. At age 20, he has a mild kind of arthritis in his elbow joint. This is common for lots of who have actually ever had joint-related trauma. The discomfort and tightness are frequently even worse during winter, when achiness might increase.

A 2000 research study revealed GLM’s anti-inflammatory effects in those with arthritis, and overall security when compared to nsaids.

A 2008 research study compared lyprinol, an extract from GLM, to naproxen and olive oil. Utilizing rodents with arthritis, researchers showed the GLM extract was much better at minimizing swelling. A 2012 study of 80 patients with osteoarthritis, over a 12-week period, did not show a substantial decrease in arthritis-related pain using a standardized discomfort scale, however researchers did note that those on the GLM utilized less acetaminophen (paracetamol), suggesting they had somewhat less pain. A 2018 research study likewise showed GLM’s benefit in lowering osteoarthritis pain. I have also come across reports of GLM being offered to canines with arthritis. The reports have actually agreed with showing pet dogs feel much better when taking this anti-inflammatory. It appears that both people, and our aged family pets, can both gain from nature’s anti-inflammatories.

Rheumatoid Arthritis

Rheumatoid arthritis is the outcome of an autoimmune condition in which the immune system attacks the lining of the joints. This leads to the damage of the cartilage and can take place at any age. There is even a kind called juvenile rheumatoid arthritis (JRA), which as the name recommends, can impact kids. It begins over the course of a few weeks or months with early morning tightness normally continuing for more than an hour. Lots of patients will have associated intestinal tract concerns and, overall, might feel tired and unhealthy.

Due to GLM’s anti-inflammatory result, it has been proposed in research studies that this supplement can be useful in minimizing swelling in those with rheumatoid arthritis. A 2000 case study reported on a client with rheumatoid arthritis who gained from GLM supplementation, while a 2007 study in BMC Complementary and Natural medicine suggested that GLM could be an useful supplement in those with rheumatoid arthritis. To date, the quantity of research studies is restricted and guaranteed advantage can not be suggested up until more research study is done. There is no evidence of damage.

Muscle Pains

Muscle aches are a typical symptom of those who participate in athletics, regular exercise and in those who work performing manual work. Frequently, one will take anti-inflammatory medications or even muscle relaxers. However, adverse effects such as stomach pain, peptic ulcer illness and sleepiness limit their usage. Lots of prefer natural options.

While magnesium is a good option for muscle spasms, GLM can be considered to assist muscle discomfort according to a 2015 study. A 2013 study showed that long-distance runners who took a green lipped mussel supplement had decreased muscle pain compared to those who did not. This is a good supplement to add to your cabinet if you are physically active.


Attention deficit hyperactivity disorder (ADHD) is a common condition affecting kids, teens, and even adults. Existing therapy concentrates on behavior modification, diet changes, and when that is not adequate prescription medication. Numerous moms and dads are concerned about drug treatment as stimulants are often the class of medications selected. These medications have side effects and can raise blood pressure, reduce hunger, and in some cases impact character in undesirable ways.

Natural therapies are often looked for to assist provide one an one-upmanship. Studies have kept in mind that those with ADHD tend to have lower levels of essential fatty acids in their blood. As a result, treatment with such is thought about.

A 2017 study of 144 children supplied half with an exclusive blend of green lipped mussel and the other half with a placebo pill. The children were followed for 14 weeks. Based on the results, the scientists concluded that GLM may be useful in lowering hyperactivity and inattention in kids with ADHD. This result is consistent with other research studies, including a meta-analysis research study supporting vital fats benefit in the treatment of those with ADHD symptoms. Due to glms overall security profile, this supplement is frequently considered. (3 ).

The manufacturing procedure of Green Lipped Mussels

Green lipped mussels were harvested from the New Zealand shoreline manually up until 1960 when the need grew. Because, the Japanese longline system of harvesting entered into effect. This method includes a longline being erupted into the open waters. The green lipped mussels find, attach and grow on the line and whilst growing, they require no food except the beautiful clear New Zealand waters.

During the 1970’s, green lipped mussels were greatly gathered and shipped to the USA. In 1981, these large deliveries stopped overnight due to strict drug legislation laws entering result. After this, the mussels have actually since been harvested and frozen and are now legal safe to ship, which rapidly became the prime export approach.

When gathered from the waters, the mussels can only live for a couple of hours so during this time the mussels are processed for freezing and then sent throughout the world for supplement usage.

The growing and collecting procedure is all natural, sustainable and similarly excellent for the environment. To be made into a supplement, the contents of the green lipped mussel is drawn out, freeze dried, ground and took into a pill. There are no contaminants or chemicals consumed or contributed to the mussels prior to export.

New Zealand Trade and Enterprise consider green lipped mussel extract to be one of the most reliable natural anti-inflammatory and joint supplements offered. It is now delivered to over 80 nations and the world’s greatest markets.

Structure of Green Lipped Mussel

Green lipped mussel supplements are made up of a number of active anti-inflammatory ingredients, just the same as raw green lipped mussels. The primary active properties are glycoproteins, omega-3 fatty acids and furan fatty acids.

It also consists of essential vitamins and minerals that are useful for joint conditions that includes vitamin C and E, zinc, copper and selenium. All chemicals, minerals and vitamins add to joint and bone health.

Glycoproteins are proteins that have sugars attached to them. These sugars are the active component which works to lower joint swelling. They are also studied and proven to have advantages for the immune system as they increase action and reactiveness to lower the effectiveness of bad germs and foreign invaders.

The essential omega-3 fatty acids likewise have anti-inflammatory impacts, which helps reduce swelling and can prevent swelling and conditions like osteoarthritis happening in the first place.

Research study discovered that green lipped mussels likewise contain other active anti-inflammatory ingredients which are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). These belong to the omega-3 fatty acids usually discovered in fish oil and hold numerous benefits for swelling of the body, consisting of the eyes, bowels, brain and heart. Your body can just make a small amount of these fats so it is necessary to consume them from other sources, like green lipped mussel supplements.

There is also an acid that is not discovered in numerous marine types and oil called eicosatetraenoic acid (ETA), which decreases the production of cyclooxygenase, an enzyme which influences swelling. This acid helps the decline and slow development of discomfort, inflammation of joints to assist movement.

The concentration of the acids found in green lipped mussels is greater than other marine oils, for that reason you require less of them to reap the benefits.

Green lipped mussels also contain furan fatty acids which help hinder the production of immune chemicals which trigger inflammation. Furan fats are an antioxidant that have been clinically evaluated for their anti-inflammation advantages and are proven to be effective.

Its makeup of minerals, vitamins, omega-3’s and antioxidants might make green lipped mussels be thought about to some as a superfood. The healthy value is greater than other marine oils and these elements can be advantageous for other locations of health too. (4 ).

The Advantages of Green Lipped Mussels for Dogs

The best known elements of green lipped mussels are Omega-3 fatty acids, consisting of the fatty acids EPA and DHA, discusses Petty. “Omega-3s work by minimizing the level of swelling related to illness such as osteoarthritis,” Petty says. Although this is the same compound discovered in fish oil, in the case of green lipped mussels, this is integrated with other compounds that likewise battle joint inflammation and pain.

A fine example of these compounds is eicosatetraenoic acid, or ETA. “The ETA is found just in green lipped mussels and binds cyclooxygenase, which is an enzyme that triggers inflammation,” according to Dr. Judy Morgan, DVM, a certified and recognized veterinary acupuncturist and food therapist who integrates holistic medicine with standard Western strategies in her practice. “They likewise consist of glucosamine, chondroitin, zinc, and magnesium, which are helpful for joint metabolism.”.

In addition, green lipped mussels have also been revealed to include glycosaminoglycans, compounds with joint protective homes, according to Petty. “A number of the other compounds in green lipped mussels such as vitamins and minerals could contribute to their pain-relieving properties, but more research needs to be done,” states Petty. (5 ).

What amount of omega-3 fats are in green-lipped mussels?

1,000 mg freeze-dried green-lipped mussel powder contains:.

  • Omega-3 EPA + DHA: 9– 28 mg
  • Omega-3 ETA: 0.3 mg

The suggested day-to-day dosages of green-lipped mussel for a pet dog that weighs 20 kilograms vary between 300 and 500 mg. It means that a pet weighing 20 kilograms gets an optimum of 15 mg omega-3 fats (ETA, EPA, DPA and DHA) from freeze-dried green-lipped mussel.

In contrast: The everyday dosage of Nutrolin ® HIP & & JOINT for a pet weighing 20 kg is 5 ml fish oil and 2 tablets. The fish oil includes 1,400 mg omega-3 fatty acids (ETA, EPA, DPA and DHA), which is almost 100 times more than in the corresponding dosage of green-lipped mussel. (6 ).

Clinical Introduction


Minimal medical research studies recommend that Perna mussel extracts might have effectiveness in the treatment of diseases with inflammatory components, such as arthritis and asthma. However, clashing trial outcomes have been reported.


Minimal medical trial data are offered to inform healing dosing. In arthritis and asthma trials, different dosages from multi-ingredient industrial preparations have been described, making it hard to develop dosing suggestions.


Hypersensitivity to shellfish. Usage with caution in individuals with hepatic problems.


Prevent use. Details regarding safety and efficacy in pregnancy and lactation is lacking. Animal studies recommend that elements of Perna extracts may have unfavorable effects on a fetus. (7 ).

Adverse effects

When taken by mouth: New Zealand green-lipped mussel is perhaps SAFE for many people. It can trigger some negative effects such as itching, gout, stomach discomfort, heart burn, diarrhea, nausea, and intestinal gas. In rare cases, it might cause liver issues. (8 ).

In research studies, green-lipped mussel has actually not triggered much in the way of side effects other than periodic moderate gastrointestinal distress. People with shellfish allergies, nevertheless, must avoid green-lipped mussel.

Unlike oysters, green-lipped mussel does not appear to consist of heavy metals. (9 ).

Green-lipped mussel products have been generally well endured however possible adverse effects have actually been explained. They might be following:

Cardiovascular: Fluid retention has actually been reported as a negative effect of green-lipped mussel use. There is also a case report from a clinical study where one client in the Lyprinol treatment group suffered cardiac arrest. The relevance of this to the treatment is uncertain.

Dermatologic: According to the The Australian Rheumatism Association, skin rash is noted as a possible adverse effect of using Seatone green-lipped mussel extract. Itching, hives and metal taste have also been reported.

Gastrointestinal: Indigestion, flatulence and moderate queasiness are possible unfavorable effecst of using Seatone greenlipped mussel extract.

Liver: The Australian Rheumatism Association reported hepatitis as a possible unfavorable result of using Seatone green-lipped mussel extracts. Possible harmful hepatitis has been related to Seatone in numerous case reports. In one scientific trial, 2 topics taking Lyprinol dropped out from the research study due to nausea and abnormal liver function, although causality is uncertain.

Musculoskeletal: Gout might be a possible adverse impact of using Seatone green-lipped mussel extract. Of rheumatoid arthritis clients taking Seatone for 90 days, 10% reported a transient worsening of signs, although no other negative events were experienced.

Neurologic/CNS: Green-lipped mussel’s B4 analog of brevetoxin B (BTXB4), has actually been identified as the major toxic substance in green-lipped mussel, and has been associated with neurotoxic shellfish poisoning.

Pulmonary/respiratory: Although green-lipped mussel extract has actually been proposed as an asthma treatment there is some data revealing that some specific people may experience difficulty breathing after consuming or inhaling green-lipped mussel items. Lung dysfunction and multiple breathing symptoms have actually been reported in New Zealand mussel openers.

Renal: Fluid retention has been reported as an adverse effects of green-lipped mussel use.

Other side results: Polioviruses have actually been discovered to survive in green-lipped mussels, both in fresh mussels and in those frozen for as much as 28 days at 20 degrees Celsius which may constitute a significant public health threat.

Safety measures and warnings during Green-lipped mussel’s items use

Usage cautiously in patients taking anti-inflammatory medications. It has actually been recommended that green-lipped mussel may improve not only the benefits of other anti-inflammatory drugs, however also their adverse results (particularly intestinal upset).

Use meticulously in clients with asthma; although green-lipped mussel has actually been recommended to have anti-asthmatic results, lung dysfunction and numerous respiratory symptoms have been reported in New Zealand mussel openers.

Prevent in clients with liver illness, due to possible poisonous hepatitis connected with green-lipped mussel.

Avoid in clients with recognized allergy/hypersensitivity to green-lipped mussel or other shellfish (mollusks, shellfishes). Powdered greenlipped mussel is reported to be more allergenic than lipid extracts; allergies to gelatin (used in pill preparations) have actually likewise been noted. (10 ).


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